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Strong oral plaque microbiome signatures for dental implant diseases identified by strain-resolution metagenomics.


ABSTRACT: Dental implants are installed in an increasing number of patients. Mucositis and peri-implantitis are common microbial-biofilm-associated diseases affecting the tissues that surround the dental implant and are a major medical and socioeconomic burden. By metagenomic sequencing of the plaque microbiome in different peri-implant health and disease conditions (113 samples from 72 individuals), we found microbial signatures for peri-implantitis and mucositis and defined the peri-implantitis-related complex (PiRC) composed by the 7 most discriminative bacteria. The peri-implantitis microbiome is site specific as contralateral healthy sites resembled more the microbiome of healthy implants, while mucositis was specifically enriched for Fusobacterium nucleatum acting as a keystone colonizer. Microbiome-based machine learning showed high diagnostic and prognostic power for peri-implant diseases and strain-level profiling identified a previously uncharacterized subspecies of F. nucleatum to be particularly associated with disease. Altogether, we associated the plaque microbiome with peri-implant diseases and identified microbial signatures of disease severity.

SUBMITTER: Ghensi P 

PROVIDER: S-EPMC7603341 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Strong oral plaque microbiome signatures for dental implant diseases identified by strain-resolution metagenomics.

Ghensi Paolo P   Manghi Paolo P   Zolfo Moreno M   Armanini Federica F   Pasolli Edoardo E   Bolzan Mattia M   Bertelle Alberto A   Dell'Acqua Federico F   Dellasega Ester E   Waldner Romina R   Tessarolo Francesco F   Tomasi Cristiano C   Segata Nicola N  

NPJ biofilms and microbiomes 20201030 1


Dental implants are installed in an increasing number of patients. Mucositis and peri-implantitis are common microbial-biofilm-associated diseases affecting the tissues that surround the dental implant and are a major medical and socioeconomic burden. By metagenomic sequencing of the plaque microbiome in different peri-implant health and disease conditions (113 samples from 72 individuals), we found microbial signatures for peri-implantitis and mucositis and defined the peri-implantitis-related  ...[more]

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