Post-translational modifications of PRC2: signals directing its activity.
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ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC7603765 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
Post-translational modifications of PRC2: signals directing its activity.
Yang Yiqi Y Li Gang G Li Gang G
Epigenetics & chromatin 20201031 1
Polycomb repressive complex 2 (PRC2) is a chromatin-modifying enzyme that catalyses the methylation of histone H3 at lysine 27 (H3K27me1/2/3). This complex maintains gene transcriptional repression and plays an essential role in the maintenance of cellular identity as well as normal organismal development. The activity of PRC2, including its genomic targeting and catalytic activity, is controlled by various signals. Recent studies have revealed that these signals involve cis chromatin features, ...[more]
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