Ontology highlight
ABSTRACT:
SUBMITTER: Gaudio E
PROVIDER: S-EPMC7604571 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Gaudio Eugenio E Tarantelli Chiara C Spriano Filippo F Guidetti Francesca F Sartori Giulio G Bordone Roberta R Arribas Alberto J AJ Cascione Luciano L Bigioni Mario M Merlino Giuseppe G Fiascarelli Alessio A Bressan Alessandro A Adjeiwaa Mensah Afua A Golino Gaetanina G Lucchini Renzo R Bernasconi Elena E Rossi Davide D Zucca Emanuele E Stussi Georg G Stathis Anastasios A Boyd Robert S RS Dusek Rachel L RL Bisht Arnima A Attanasio Nickolas N Rohlff Christian C Pellacani Andrea A Binaschi Monica M Bertoni Francesco F
Haematologica 20201101 11
Antibody drug conjugates represent an important class of anti-cancer drugs in both solid tumors and hematological cancers. Here, we report preclinical data on the anti-tumor activity of the first-in-class antibody drug conjugate MEN1309/OBT076 targeting CD205. The study included preclinical in vitro activity screening on a large panel of cell lines, both as single agent and in combination and validation experiments on in vivo models. CD205 was first shown frequently expressed in lymphomas, leuke ...[more]