Nimodipine improves cortical efficiency during working memory in healthy subjects.
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ABSTRACT:
SUBMITTER: Zink CF
PROVIDER: S-EPMC7606375 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
Nimodipine improves cortical efficiency during working memory in healthy subjects.
Zink Caroline F CF Giegerich Mellissa M Prettyman Greer E GE Carta Kayla E KE van Ginkel Marcus M O'Rourke Molly P MP Singh Eesha E Fuchs Edward J EJ Hendrix Craig W CW Zimmerman Eric E Breakey Jennifer J Marzinke Mark A MA Hummert Pamela P Pillai Jay J JJ Weinberger Daniel R DR Bigos Kristin L KL
Translational psychiatry 20201102 1
The L-type calcium channel gene, CACNA1C, is a validated risk gene for schizophrenia and the target of calcium channel blockers. Carriers of the risk-associated genotype (rs1006737 A allele) have increased frontal cortical activity during working memory and higher CACNA1C mRNA expression in the prefrontal cortex. The aim of this study was to determine how the brain-penetrant calcium channel blocker, nimodipine, changes brain activity during working memory and other cognitive and emotional proces ...[more]
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