Ontology highlight
ABSTRACT:
SUBMITTER: Thompson HA
PROVIDER: S-EPMC7607256 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Thompson Hayley A HA Hogan Alexandra B AB Walker Patrick G T PGT White Michael T MT Cunnington Aubrey J AJ Ockenhouse Christian F CF Ghani Azra C AC
Vaccine 20201009 47
Anti-circumsporozoite antibody titres have been established as an essential indicator for evaluating the immunogenicity and protective capacity of the RTS,S/AS01 malaria vaccine. However, a new delayed-fractional dose regime of the vaccine was recently shown to increase vaccine efficacy, from 62.5% (95% CI 29.4-80.1%) under the original dosing schedule to 86.7% (95% CI, 66.8-94.6%) without a corresponding increase in antibody titres. Here we reanalyse the antibody data from this challenge trial ...[more]