Ontology highlight
ABSTRACT:
SUBMITTER: Wei H
PROVIDER: S-EPMC7609734 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Wei Hui H Zhang Hui-Liang HL Wang Xiao-Chuan XC Xie Jia-Zhao JZ An Dan-Dan DD Wan Lu L Wang Jian-Zhi JZ Zeng Yi Y Shu Xi-Ji XJ Westermarck Jukka J Lu You-Ming YM Ohlmeyer Michael M Liu Rong R
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20200701 3
Alzheimer's disease (AD) is a multifactorial neurodegenerative disease for which there are limited therapeutic strategies. Protein phosphatase 2A (PP2A) activity is decreased in AD brains, which promotes the hyperphosphorylation of Tau and APP, thus participate in the formation of neurofibrillary tangles (NFTs) and β-amyloid (Aβ) overproduction. In this study, the effect of synthetic tricyclic sulfonamide PP2A activators (aka SMAPs) on reducing AD-like pathogenesis was evaluated in AD cell model ...[more]