Spinal astroglial cannabinoid receptors control pathological tremor.
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ABSTRACT:
SUBMITTER: Carlsen EMM
PROVIDER: S-EPMC7610740 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Publications
Spinal astroglial cannabinoid receptors control pathological tremor.
Carlsen Eva Maria Meier EMM Falk Sarah S Skupio Urszula U Robin Laurie L Pagano Zottola Antonio C AC Marsicano Giovanni G Perrier Jean-François JF
Nature neuroscience 20210318 5
Cannabinoids reduce tremor associated with motor disorders induced by injuries and neurodegenerative disease. Here we show that this effect is mediated by cannabinoid receptors on astrocytes in the ventral horn of the spinal cord, where alternating limb movements are initiated. We first demonstrate that tremor is reduced in a mouse model of essential tremor after intrathecal injection of the cannabinoid analog WIN55,212-2. We investigate the underlying mechanism using electrophysiological record ...[more]
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