Animal Models for the Study of Nucleic Acid Immunity: Novel Tools and New Perspectives.

ABSTRACT: Unresolved inflammation fosters and supports a wide range of human pathologies. There is growing evidence for a role played by cytosolic nucleic acids in initiating and supporting pathological chronic inflammation. In particular, the cGAS-STING pathway has emerged as central to the mounting of nucleic acid-dependent type I interferon responses, leading to the identification of small-molecule modulators of STING that have raised clinical interest. However, several new challenges have emerged, representing potential obstacles to efficient clinical translation. Indeed, the current literature underscores that nucleic acid-induced inflammatory responses are subjected to several layers of regulation, further suggesting complex coordination at the cell-type, tissue or organism level. Untangling t

SUBMITTER: Vila IK 

PROVIDER: S-EPMC7611023 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature