Dataset Information

A Degradable and Antimicrobial Surface-attached Polymer Hydrogela.

ABSTRACT: Surface-attached, degradable polymer hydrogels with potential antimicrobial activity are reported. They were obtained by ring-opening metathesis copolymerization (ROMP) of a monomer with potential bioactivity and a monomer that carries a benzophenone cross-linker and a hydrolyzable group. The hydrolyzable group was either an ester or an anhydride group. The copolymers thus obtained were spin-coated onto silicon wafers and UV-irradiated to induce C,H cross-linking of the benzophenone groups and obtain the target polymer networks. Immersion of these networks into aqueous media triggered network degradation. The degradation speed depended on the nature of the intended break points (ester or anhydride groups), the number of cross-links per polymer chain, and the surrounding medium. By releasing bioactive polymer fragments to the medium ("leaching") and by regenerating the hydrogel surface during the degradation process, the hydrogels potentially have two ways to prevent biofilm formation on their surface.

SUBMITTER: Erath R

PROVIDER: S-EPMC7611506 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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A Degradable and Antimicrobial Surface-attached Polymer Hydrogel<sup>a</sup>.

Erath Roman R Lienkamp Karen K

Macromolecular chemistry and physics 20180731 17

Surface-attached, degradable polymer hydrogels with potential antimicrobial activity are reported. They were obtained by ring-opening metathesis copolymerization (ROMP) of a monomer with potential bioactivity and a monomer that carries a benzophenone cross-linker and a hydrolyzable group. The hydrolyzable group was either an ester or an anhydride group. The copolymers thus obtained were spin-coated onto silicon wafers and UV-irradiated to induce C,H cross-linking of the benzophenone groups and o ...[more]

PMID: 34404978

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Project description:The lateral dimensions of micro- and nanostructures obtained by microcontact printing (μCP) can be easily varied by selecting stamps with the desired spacing and pattern. However, the height of these structures cannot be tuned as easily, and in most cases only 2D structures are obtained. Here, we show how the chemical cross-linking properties of polymer inks designed for μCP can be used to obtain 3D structures with heights ranging from 3 to 750 nm using the same μCP stamps. This is technologically relevant because the ink concentration affects the quality and resolution of the printed image, and therefore can only be varied in a certain range. By exploiting the cross-linking efficiency to tune the height, an additional parameter is available to reach the desired structure height without compromising the image quality. The inks were made from copolymers containing a low percentage of different UV cross-linkable repeat units: nitrobenzoxadiazole (NBD), coumarin (COU), and/or benzophenone (BP). The base polymer of the here presented model system was an antimicrobially active poly(oxanorbornene) (SMAMP), however the concept should be transferable to many other polymer backbones. We describe the fabrication and characterization of the printed micro- and nanostructures made from pure SMAMP, NBD-SMAMP, coumarin-SMAMP, BP-SMAMP, BP-NBD-SMAMP and BP-coumarin-SMAMP polymer inks. The photo-dimerization of COU during UV irradiation at λ = 254 nm was confirmed by UV-Vis spectroscopy. Since NBD and COU are fluorescent, the polymer could be visualized by fluorescence microscopy. Additionally, their height profiles were measured by atomic force microscopy (AFM). The heights of the 3D surface-attached polymer networks obtained from the here presented polymer inks correlated with the gel-content of the corresponding unstructured polymer layers, and thus with the cross-linking efficiency of the NBD, COU and BP cross-linkers. Due to being covalently cross-linked, these 3D-surface attached polymer structures were solvent-stable and stable in aqueous surroundings.

Dataset Information

A Degradable and Antimicrobial Surface-attached Polymer Hydrogela.

Publications

A Degradable and Antimicrobial Surface-attached Polymer Hydrogel<sup>a</sup>.

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