A role for the cortex in sleep-wake regulation.
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ABSTRACT:
SUBMITTER: Krone LB
PROVIDER: S-EPMC7612118 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
A role for the cortex in sleep-wake regulation.
Krone Lukas B LB Yamagata Tomoko T Blanco-Duque Cristina C Guillaumin Mathilde C C MCC Kahn Martin C MC van der Vinne Vincent V McKillop Laura E LE Tam Shu K E SKE Peirson Stuart N SN Akerman Colin J CJ Hoerder-Suabedissen Anna A Molnár Zoltán Z Vyazovskiy Vladyslav V VV
Nature neuroscience 20210802 9
Cortical and subcortical circuitry are thought to play distinct roles in the generation of sleep oscillations and global state control, respectively. Here we silenced a subset of neocortical layer 5 pyramidal and archicortical dentate gyrus granule cells in male mice by ablating SNAP25. This markedly increased wakefulness and reduced rebound of electroencephalographic slow-wave activity after sleep deprivation, suggesting a role for the cortex in both vigilance state control and sleep homeostasi ...[more]
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