Dataset Information

Left Vagus Stimulation Modulates Contralateral Subthalamic β Power Improving the Gait in Parkinson's Disease.

ABSTRACT:

Background

Transcutaneous vagus nerve stimulation (VNS) showed early evidence of efficacy for the gait treatment of Parkinson's disease (PD).

Objectives

Providing data on neurophysiological and clinical effects of transauricular VNS (taVNS).

Methods

Ten patients with recording deep brain stimulation (DBS) have been enrolled in a within participant design pilot study, double-blind crossover sham-controlled trial of taVNS. Subthalamic local field potentials (β band power), Unified Parkinson's Disease Rating Scales (UPDRS), and a digital timed-up-and-go test (TUG) were measured and compared with real versus sham taVNS during medication-off/DBS-OFF condition.

Results

The left taVNS induced a reduction of the total β power in the contralateral (ie, right) subthalamic nucleus and an improvement of TUG time, speed, and variability. The taVNS-induced β reduction correlated with the improvement of gait speed. No major clinical changes were observed at UPDRS.

Conclusions

taVNS is a promising strategy for the management of PD gait, deserving prospective trials of chronic neuromodulation. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

SUBMITTER: Marano M

PROVIDER: S-EPMC7615838 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature

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Publications

Left Vagus Stimulation Modulates Contralateral Subthalamic β Power Improving the Gait in Parkinson's Disease.

Marano Massimo M Anzini Gaia G Saltarocchi Luca L Ricciuti Riccardo R Capone Fioravante F Tan Huiling H Torrecillos Flavie F Lanzone Jacopo J Di Lazzaro Vincenzo V

Movement disorders : official journal of the Movement Disorder Society 20231218 2

<h4>Background</h4>Transcutaneous vagus nerve stimulation (VNS) showed early evidence of efficacy for the gait treatment of Parkinson's disease (PD).<h4>Objectives</h4>Providing data on neurophysiological and clinical effects of transauricular VNS (taVNS).<h4>Methods</h4>Ten patients with recording deep brain stimulation (DBS) have been enrolled in a within participant design pilot study, double-blind crossover sham-controlled trial of taVNS. Subthalamic local field potentials (β band power), Un ...[more]

PMID: 38111224

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Dataset Information

Left Vagus Stimulation Modulates Contralateral Subthalamic β Power Improving the Gait in Parkinson's Disease.

Background

Objectives

Methods

Results

Conclusions

Publications

Left Vagus Stimulation Modulates Contralateral Subthalamic β Power Improving the Gait in Parkinson's Disease.

Similar Datasets

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