Ontology highlight
ABSTRACT:
SUBMITTER: Wypijewska Del Nogal A
PROVIDER: S-EPMC7641321 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Wypijewska Del Nogal Anna A Füchtbauer Anders F AF Bood Mattias M Nilsson Jesper R JR Wranne Moa S MS Sarangamath Sangamesh S Pfeiffer Pauline P Rajan Vinoth Sundar VS El-Sagheer Afaf H AH Dahlén Anders A Brown Tom T Grøtli Morten M Wilhelmsson L Marcus LM
Nucleic acids research 20200801 14
With the central role of nucleic acids there is a need for development of fluorophores that facilitate the visualization of processes involving nucleic acids without perturbing their natural properties and behaviour. Here, we incorporate a new analogue of adenine, 2CNqA, into both DNA and RNA, and evaluate its nucleobase-mimicking and internal fluorophore capacities. We find that 2CNqA displays excellent photophysical properties in both nucleic acids, is highly specific for thymine/uracil, and m ...[more]