Ontology highlight
ABSTRACT:
SUBMITTER: Zou P
PROVIDER: S-EPMC4134104 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Nature communications 20140813
Genetically encoded fluorescent reporters of membrane potential promise to reveal aspects of neural function not detectable by other means. We present a palette of multicoloured brightly fluorescent genetically encoded voltage indicators with sensitivities from 8-13% ΔF/F per 100 mV, and half-maximal response times from 4-7 ms. A fluorescent protein is fused to an archaerhodopsin-derived voltage sensor. Voltage-induced shifts in the absorption spectrum of the rhodopsin lead to voltage-dependent ...[more]