Ontology highlight
ABSTRACT:
SUBMITTER: Single RM
PROVIDER: S-EPMC7641399 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Single Richard M RM Meyer Diogo D Nunes Kelly K Francisco Rodrigo Santos RS Hünemeier Tábita T Maiers Martin M Hurley Carolyn K CK Bedoya Gabriel G Gallo Carla C Hurtado Ana Magdalena AM Llop Elena E Petzl-Erler Maria Luiza ML Poletti Giovanni G Rothhammer Francisco F Tsuneto Luiza L Klitz William W Ruiz-Linares Andrés A
PloS one 20201104 11
The American continent was the last to be occupied by modern humans, and native populations bear the marks of recent expansions, bottlenecks, natural selection, and population substructure. Here we investigate how this demographic history has shaped genetic variation at the strongly selected HLA loci. In order to disentangle the relative contributions of selection and demography process, we assembled a dataset with genome-wide microsatellites and HLA-A, -B, -C, and -DRB1 typing data for a set of ...[more]