Ontology highlight
ABSTRACT:
SUBMITTER: Ratushny V
PROVIDER: S-EPMC3204164 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Ratushny V V Pathak H B HB Beeharry N N Tikhmyanova N N Xiao F F Li T T Litwin S S Connolly D C DC Yen T J TJ Weiner L M LM Godwin A K AK Golemis E A EA
Oncogene 20110725 10
Increased activity of SRC family kinases promotes tumor invasion and metastasis, and overexpression of the mitotic regulator Aurora kinase A (AURKA) drives tumor aneuploidy and chromosomal instability. These functions nominate SRC and AURKA as valuable therapeutic targets for cancer, and inhibitors for SRC and Aurora kinases are now being used in the clinic. In this study, we demonstrate potent synergy between multiple inhibitors of Aurora and SRC kinases in ovarian and colorectal cancer cell li ...[more]