Mechanistic insights into energy conservation by flavin-based electron bifurcation.
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ABSTRACT:
SUBMITTER: Lubner CE
PROVIDER: S-EPMC7646311 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Publications
Mechanistic insights into energy conservation by flavin-based electron bifurcation.
Lubner Carolyn E CE Jennings David P DP Mulder David W DW Schut Gerrit J GJ Zadvornyy Oleg A OA Hoben John P JP Tokmina-Lukaszewska Monika M Berry Luke L Nguyen Diep M DM Lipscomb Gina L GL Bothner Brian B Jones Anne K AK Miller Anne-Frances AF King Paul W PW Adams Michael W W MWW Adams Michael W W MWW Peters John W JW
Nature chemical biology 20170410 6
The recently realized biochemical phenomenon of energy conservation through electron bifurcation provides biology with an elegant means to maximize utilization of metabolic energy. The mechanism of coordinated coupling of exergonic and endergonic oxidation-reduction reactions by a single enzyme complex has been elucidated through optical and paramagnetic spectroscopic studies revealing unprecedented features. Pairs of electrons are bifurcated over more than 1 volt of electrochemical potential by ...[more]
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