De Novo A-to-I RNA Editing Discovery in lncRNA.

ABSTRACT:

Background

Adenosine to inosine (A-to-I) RNA editing is the most frequent editing event in humans. It converts adenosine to inosine in double-stranded RNA regions (in coding and non-coding RNAs) through the action of the adenosine deaminase acting on RNA (ADAR) enzymes. Long non-coding RNAs, particularly abundant in the brain, account for a large fraction of the human transcriptome, and their important regulatory role is becoming progressively evident in both normal and transformed cells.

Results

Herein, we present a bioinformatic analysis to generate a comprehensive inosinome picture in long non-coding RNAs (lncRNAs), using an ad hoc index and searching for de novo editing events in the normal brain cortex as well as in glioblastoma, a highly aggressive human brain cancer.

SUBMITTER: Silvestris DA 

PROVIDER: S-EPMC7650826 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature