Dataset Information

SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020.

ABSTRACT: SARS-CoV-2 IgG screening of 1,000 antenatal serum samples in the Oxford area, United Kingdom, between 14 April and 15 June 2020, yielded a 5.3% seroprevalence, mirroring contemporaneous regional data. Among the 53 positive samples, 39 showed in vitro neutralisation activity, correlating with IgG titre (Pearson's correlation p<0.0001). While SARS-CoV-2 seroprevalence in pregnancy cohorts could potentially inform population surveillance, clinical correlates of infection and immunity in pregnancy, and antenatal epidemiology evolution over time need further study.

SUBMITTER: Lumley SF

PROVIDER: S-EPMC7651878 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020.

Lumley Sheila F SF Eyre David W DW McNaughton Anna L AL Howarth Alison A Hoosdally Sarah S Hatch Stephanie B SB Kavanagh James J Chau Kevin K KK Downs Louise O LO Cox Stuart S Dunn Laura L Justice Anita A Wareing Susan S Dingle Kate K Rudkin Justine J Auckland Kathryn K Fyfe Alexander A Bolton Jai J Paton Robert R Mentzer Alexander J AJ Jeffery Katie K Andersson Monique I MI James Tim T Peto Tim E A TEA Marsden Brian D BD Screaton Gavin G Cornall Richard J RJ Klenerman Paul P Ebner Daniel D Stuart David I DI Crook Derrick W DW Stoesser Nicole N Kennedy Stephen H SH Thompson Craig C Gupta Sunetra S Matthews Philippa C PC

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20201001 42

SARS-CoV-2 IgG screening of 1,000 antenatal serum samples in the Oxford area, United Kingdom, between 14 April and 15 June 2020, yielded a 5.3% seroprevalence, mirroring contemporaneous regional data. Among the 53 positive samples, 39 showed in vitro neutralisation activity, correlating with IgG titre (Pearson's correlation p<0.0001). While SARS-CoV-2 seroprevalence in pregnancy cohorts could potentially inform population surveillance, clinical correlates of infection and immunity in pregnancy, ...[more]

PMID: 33094717

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Dataset Information

SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020.

Publications

SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020.

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