Ontology highlight
ABSTRACT:
SUBMITTER: Rabesandratana O
PROVIDER: S-EPMC7652757 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Rabesandratana Oriane O Chaffiol Antoine A Mialot Antoine A Slembrouck-Brec Amélie A Joffrois Corentin C Nanteau Céline C Rodrigues Amélie A Gagliardi Giuliana G Reichman Sacha S Sahel José-Alain JA Chédotal Alain A Duebel Jens J Goureau Olivier O Orieux Gael G
Frontiers in cell and developmental biology 20201027
Optic neuropathies are a major cause of visual impairment due to retinal ganglion cell (RGC) degeneration. Human induced-pluripotent stem cells (iPSCs) represent a powerful tool for studying both human RGC development and RGC-related pathological mechanisms. Because RGC loss can be massive before the diagnosis of visual impairment, cell replacement is one of the most encouraging strategies. The present work describes the generation of functional RGCs from iPSCs based on innovative 3D/2D stepwise ...[more]