Ontology highlight
ABSTRACT:
SUBMITTER: Klimentova E
PROVIDER: S-EPMC7653191 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Klimentova Eva E Polacek Jakub J Simecek Petr P Alexiou Panagiotis P
Frontiers in genetics 20201027
G-quadruplexes (G4s) are a class of stable structural nucleic acid secondary structures that are known to play a role in a wide spectrum of genomic functions, such as DNA replication and transcription. The classical understanding of G4 structure points to four variable length guanine strands joined by variable length nucleotide stretches. Experiments using G4 immunoprecipitation and sequencing experiments have produced a high number of highly probable G4 forming genomic sequences. The expense an ...[more]