Ontology highlight
ABSTRACT:
SUBMITTER: Mata DA
PROVIDER: S-EPMC7653727 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Mata Douglas A DA Benhamida Jamal K JK Lin Andrew L AL Vanderbilt Chad M CM Yang Soo-Ryum SR Villafania Liliana B LB Ferguson Donna C DC Jonsson Philip P Miller Alexandra M AM Tabar Viviane V Brennan Cameron W CW Moss Nelson S NS Sill Martin M Benayed Ryma R Mellinghoff Ingo K IK Rosenblum Marc K MK Arcila Maria E ME Ladanyi Marc M Bale Tejus A TA
Acta neuropathologica communications 20201109 1
A subset of glioblastomas (GBMs) harbors potentially druggable oncogenic FGFR3-TACC3 (F3T3) fusions. However, their associated molecular and clinical features are poorly understood. Here we analyze the frequency of F3T3-fusion positivity, its associated genetic and methylation profiles, and its impact on survival in 906 IDH-wildtype GBM patients. We establish an F3T3 prevalence of 4.1% and delineate its associations with cancer signaling pathway alterations. F3T3-positive GBMs had lower tumor mu ...[more]