Ontology highlight
ABSTRACT:
SUBMITTER: de Vries RD
PROVIDER: S-EPMC7654853 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
de Vries Rory D RD Schmitz Katharina S KS Bovier Francesca T FT Noack Danny D Haagmans Bart L BL Biswas Sudipta S Rockx Barry B Gellman Samuel H SH Alabi Christopher A CA de Swart Rik L RL Moscona Anne A Porotto Matteo M
bioRxiv : the preprint server for biology 20201105
Containment of the COVID-19 pandemic requires reducing viral transmission. SARS-CoV-2 infection is initiated by membrane fusion between the viral and host cell membranes, mediated by the viral spike protein. We have designed a dimeric lipopeptide fusion inhibitor that blocks this critical first step of infection for emerging coronaviruses and document that it completely prevents SARS-CoV-2 infection in ferrets. Daily intranasal administration to ferrets completely prevented SARS-CoV-2 direct-con ...[more]