Ontology highlight
ABSTRACT:
SUBMITTER: Fontana D
PROVIDER: S-EPMC7655091 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Fontana Diletta D Ramazzotti Daniele D Aroldi Andrea A Redaelli Sara S Magistroni Vera V Pirola Alessandra A Niro Antonio A Massimino Luca L Mastini Cristina C Brambilla Virginia V Bombelli Silvia S Bungaro Silvia S Morotti Alessandro A Rea Delphine D Stagno Fabio F Martino Bruno B Campiotti Leonardo L Caocci Giovanni G Usala Emilio E Merli Michele M Onida Francesco F Bregni Marco M Elli Elena Maria EM Fumagalli Monica M Ciceri Fabio F Perego Roberto A RA Pagni Fabio F Mologni Luca L Piazza Rocco R Gambacorti-Passerini Carlo C
HemaSphere 20201106 6
Atypical chronic myeloid leukemia (aCML) is a <i>BCR-ABL1</i>-negative clonal disorder, which belongs to the myelodysplastic/myeloproliferative group. This disease is characterized by recurrent somatic mutations in <i>SETBP1</i>, <i>ASXL1</i> and <i>ETNK1</i> genes, as well as high genetic heterogeneity, thus posing a great therapeutic challenge. To provide a comprehensive genomic characterization of aCML we applied a high-throughput sequencing strategy to 43 aCML samples, including both whole-e ...[more]