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Total Synthesis of Meayamycin and O-Acyl Analogues.


ABSTRACT: A short, scalable total synthesis of meayamycin is described by an approach that entails a longest linear sequence of 12 steps (22 steps overall) from commercially available chiral pool materials (ethyl l-lactate, BocNH-Thr-OH, and d-ribose) and introduces the most straightforward preparation of the right-hand subunit detailed to date. The use of the approach in the divergent synthesis of a representative series of O-acyl analogues is exemplified.

SUBMITTER: Gartshore C 

PROVIDER: S-EPMC7655641 | biostudies-literature |

REPOSITORIES: biostudies-literature

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