Ontology highlight
ABSTRACT:
SUBMITTER: Lee IG
PROVIDER: S-EPMC7655957 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Lee In-Gyun IG Cason Sydney E SE Alqassim Saif S SS Holzbaur Erika L F ELF Dominguez Roberto R
Nature communications 20201110 1
Cytoplasmic dynein-1 (dynein) is the motor responsible for most retrograde transport of cargoes along microtubules in eukaryotic cells, including organelles, mRNA and viruses. Cargo selectivity and activation of processive motility depend on a group of so-called "activating adaptors" that link dynein to its general cofactor, dynactin, and cargoes. The mechanism by which these adaptors regulate dynein transport is poorly understood. Here, based on crystal structures, quantitative binding studies, ...[more]