Ontology highlight
ABSTRACT:
SUBMITTER: Keator DB
PROVIDER: S-EPMC7656170 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Alzheimer's & dementia (Amsterdam, Netherlands) 20201111 1
<h4>Introduction</h4>Down syndrome (DS) is associated with elevated risk for Alzheimer's disease (AD) due to amyloid beta (Aβ) lifelong accumulation. We hypothesized that the spatial distribution of brain Aβ predicts future dementia conversion in individuals with DS.<h4>Methods</h4>We acquired <sup>18</sup>F-florbetapir positron emission tomography scans from 19 nondemented individuals with DS at baseline and monitored them for 4 years, with five individuals transitioning to dementia. Machine le ...[more]