Ontology highlight
ABSTRACT:
SUBMITTER: Itoh G
PROVIDER: S-EPMC7657133 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Itoh Go G Sugino Shiro S Ikeda Masanori M Mizuguchi Mayumi M Kanno Shin-ichiro S Amin Mohammed A MA Iemura Kenji K Yasui Akira A Hirota Toru T Tanaka Kozo K
Cancer science 20130502 7
Most cancer cells are aneuploid, which could be caused by defects in chromosome segregation machinery. Nucleoporins (Nup) are components of the nuclear pore complex, which is essential for nuclear transport during interphase, but several nucleoporins are also known to be involved in chromosome segregation. Here we report a novel function of Nup188, one of the nucleoporins regulating chromosome segregation. Nup188 localizes to spindle poles during mitosis, through the C-terminal region of Nup188. ...[more]