Ontology highlight
ABSTRACT:
SUBMITTER: Maiden MM
PROVIDER: S-EPMC7657502 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Maiden Michael M MM Maiden Michael M MM Waters Christopher M CM
PLoS pathogens 20201030 10
Biofilm-based infections are difficult to treat due to their inherent resistance to antibiotic treatment. Discovering new approaches to enhance antibiotic efficacy in biofilms would be highly significant in treating many chronic infections. Exposure to aminoglycosides induces adaptive resistance in Pseudomonas aeruginosa biofilms. Adaptive resistance is primarily the result of active antibiotic export by RND-type efflux pumps, which use the proton motive force as an energy source. We show that t ...[more]