Ontology highlight
ABSTRACT:
SUBMITTER: Marzouka NA
PROVIDER: S-EPMC7658206 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Marzouka Nour-Al-Dain NA Lindgren David D Eriksson Pontus P Sjödahl Gottfrid G Bernardo Carina C Liedberg Fredrik F Axelson Håkan H Höglund Mattias M
Scientific reports 20201111 1
We used the fact that patients with non-muscle invasive bladder tumors show local recurrences and multiple tumors to study re-initiation of tumor growth from the same urothelium. By extensive genomic analyses we show that tumors from the same patient are clonal. We show that gross genomic chromosomal aberrations may be detected in one tumor, only to be undetected in a recurrent tumor. By analyses of incompatible changes i.e., genomic alterations that cannot be reversed, we show that almost all t ...[more]