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Comparative and cumulative quantitative risk assessments on a novel heated tobacco product versus the 3R4F reference cigarette.

ABSTRACT: Novel tobacco products that heat rather than burn tobacco (heated tobacco products or HTPs) have been shown to produce lower levels of harmful and potentially harmful constituents than conventional combusted cigarettes. The present study uses a quantitative risk assessment approach to compare non-cancer and cancer risk estimates for emissions generated by an HTP with smoke from a reference cigarette (3R4F). Fifty-four analytes were evaluated from the HTP aerosol and the 3R4F cigarette smoke. Emissions were generated using the ISO and the Health Canada Intense smoking regimes. The measured values were extrapolated to define a conservative exposure assumption for per day use and lifetime use based on an estimated maximum usage level of 400 puffs per day i.e., approximately 8 HTP tobacco capsules or 40 combustible cigarettes. Non-cancer and cancer risk estimates were calculated using these exposure assumptions for individual and per health outcome domains based on toxicological reference values derived by regulatory and/or public health agencies. The results of this assessment showed a reduction of non-cancer and cancer risk estimates by more than 90 % for the HTP versus the 3R4F cigarette, regardless of the smoking regime.

SUBMITTER: Hirn C

PROVIDER: S-EPMC7658373 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Comparative and cumulative quantitative risk assessments on a novel heated tobacco product versus the 3R4F reference cigarette.

Hirn Carole C Kanemaru Yuki Y Stedeford Todd T Paschke Thilo T Baskerville-Abraham Irene I

Toxicology reports 20201102

Novel tobacco products that heat rather than burn tobacco (heated tobacco products or HTPs) have been shown to produce lower levels of harmful and potentially harmful constituents than conventional combusted cigarettes. The present study uses a quantitative risk assessment approach to compare non-cancer and cancer risk estimates for emissions generated by an HTP with smoke from a reference cigarette (3R4F). Fifty-four analytes were evaluated from the HTP aerosol and the 3R4F cigarette smoke. Emi ...[more]

PMID: 33209587

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Dataset Information

Comparative and cumulative quantitative risk assessments on a novel heated tobacco product versus the 3R4F reference cigarette.

Publications

Comparative and cumulative quantitative risk assessments on a novel heated tobacco product versus the 3R4F reference cigarette.

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