Ontology highlight
ABSTRACT:
SUBMITTER: Brazeau NF
PROVIDER: S-EPMC7658547 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Evolution, medicine, and public health 20200907 1
Daptomycin (DAP) is key in treating multidrug-resistant <i>Staphylococcus</i> infections. Diminished susceptibility to DAP is emerging among <i>Staphylococcus epidermidis</i> strains although mechanisms for non-susceptibility (NS) remain poorly understood. We report a case of persistent <i>S. epidermidis</i> bacteremia in which loss of DAP susceptibility arose during prolonged treatment. Whole genome sequencing identified two mutations, Q371del and P415L, in a single-affected gene, <i>WalK</i>, ...[more]