Ontology highlight
ABSTRACT:
SUBMITTER: Chesnel F
PROVIDER: S-EPMC7660911 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
PLoS genetics 20201102 11
Loss of von Hippel-Lindau protein pVHL function promotes VHL diseases, including sporadic and inherited clear cell Renal Cell Carcinoma (ccRCC). Mechanisms controlling pVHL function and regulation, including folding and stability, remain elusive. Here, we have identified the conserved cochaperone prefoldin complex in a screen for pVHL interactors. The prefoldin complex delivers non-native proteins to the chaperonin T-complex-protein-1-ring (TRiC) or Cytosolic Chaperonin containing TCP-1 (CCT) to ...[more]