Ontology highlight
ABSTRACT:
SUBMITTER: Fahling M
PROVIDER: S-EPMC3810090 | biostudies-other | 2013 Nov
REPOSITORIES: biostudies-other
Journal of the American Society of Nephrology : JASN 20130822 11
Renal hypoxia occurs in AKI of various etiologies, but adaptation to hypoxia, mediated by hypoxia-inducible factor (HIF), is incomplete in these conditions. Preconditional HIF activation protects against renal ischemia-reperfusion injury, yet the mechanisms involved are largely unknown, and HIF-mediated renoprotection has not been examined in other causes of AKI. Here, we show that selective activation of HIF in renal tubules, through Pax8-rtTA-based inducible knockout of von Hippel-Lindau prote ...[more]