Ontology highlight
ABSTRACT:
SUBMITTER: Garcia S
PROVIDER: S-EPMC7662212 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
García Santiago S Mercado-Sánchez Itzel I Bahena Luis L Alcaraz Yolanda Y García-Revilla Marco A MA Robles Juvencio J Santos-Martínez Nancy N Ordaz-Rosado David D García-Becerra Rocío R Vazquez Miguel A MA
Molecules (Basel, Switzerland) 20201104 21
Coumarin-hydroxamic acid derivatives <b>7a</b>-<b>k</b> were herein designed with a dual purpose: as antiproliferative agents and fluorescent probes. The compounds were synthesized in moderate yields (30-87%) through a simple methodology, biological evaluation was carried out on prostate (PC3) and breast cancer (BT-474 and MDA-MB-231) cell lines to determine the effects on cell proliferation and gene expression. For compounds <b>7c</b>, <b>7e</b>, <b>7f</b>, <b>7i</b> and <b>7j</b> the inhibitio ...[more]