Ontology highlight
ABSTRACT:
SUBMITTER: Coate KC
PROVIDER: S-EPMC7664344 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Coate Katie C KC Cha Jeeyeon J Shrestha Shristi S Wang Wenliang W Gonçalves Luciana Mateus LM Almaça Joana J Kapp Meghan E ME Fasolino Maria M Morgan Ashleigh A Dai Chunhua C Saunders Diane C DC Bottino Rita R Aramandla Radhika R Jenkins Regina R Stein Roland R Kaestner Klaus H KH Vahedi Golnaz G Brissova Marcela M Powers Alvin C AC
Cell metabolism 20201113 6
Isolated reports of new-onset diabetes in individuals with COVID-19 have led to the hypothesis that SARS-CoV-2 is directly cytotoxic to pancreatic islet β cells. This would require binding and entry of SARS-CoV-2 into β cells via co-expression of its canonical cell entry factors, angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2); however, their expression in human pancreas has not been clearly defined. We analyzed six transcriptional datasets of primary human i ...[more]