Ontology highlight
ABSTRACT:
SUBMITTER: Gilchrist AM
PROVIDER: S-EPMC7664440 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20201106 21
Synthetic anion transporters that facilitate chloride transport are promising candidates for channelopathy treatments. However, most anion transporters exhibit an undesired side effect of facilitating proton transport via interacting with fatty acids present in the membrane. To address the limitation, we here report the use of a new tetrapodal scaffold to maximize the selective interaction with spherical chloride over binding the carboxylate headgroup of fatty acids. One of the new transporters ...[more]