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Engineering bioactive surfaces on nanoparticles and their biological interactions.

ABSTRACT: The successful integration of nanoparticles into biomedical applications requires modulation of their surface properties so that the interaction with biological systems is regulated to minimize toxicity for biological function. In the present work, we have engineered bioactive surfaces on gold (Au) and silver (Ag) nanoparticles and subsequently evaluated their interaction with mouse skin fibroblasts and macrophages. The Au and Ag nanoparticles were synthesized using tyrosine, tryptophan, isonicotinylhydrazide, epigallocatechin gallate, and curcumin as reducing and stabilizing agents. The nanoparticles thus prepared showed surface corona and exhibited free radical scavenging and enzyme activities with limited cytotoxicity and genotoxicity. We have thus developed avenues for engineering the surface of nanoparticles for biological applications.

SUBMITTER: Matur M

PROVIDER: S-EPMC7665184 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Engineering bioactive surfaces on nanoparticles and their biological interactions.

Matur Meghana M Madhyastha Harishkumar H Shruthi T S TS Madhyastha Radha R Srinivas S P SP Navya P N PN Daima Hemant Kumar HK

Scientific reports 20201112 1

The successful integration of nanoparticles into biomedical applications requires modulation of their surface properties so that the interaction with biological systems is regulated to minimize toxicity for biological function. In the present work, we have engineered bioactive surfaces on gold (Au) and silver (Ag) nanoparticles and subsequently evaluated their interaction with mouse skin fibroblasts and macrophages. The Au and Ag nanoparticles were synthesized using tyrosine, tryptophan, isonico ...[more]

PMID: 33184324

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