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Prediction of Maternal and Fetal Pharmacokinetics of Dolutegravir and Raltegravir Using Physiologically Based Pharmacokinetic Modeling.

ABSTRACT:

Background

Predicting drug pharmacokinetics in pregnant women including placental drug transfer remains challenging. This study aimed to develop and evaluate maternal-fetal physiologically based pharmacokinetic models for two antiretroviral drugs, dolutegravir and raltegravir.

SUBMITTER: Liu XI

PROVIDER: S-EPMC7666002 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Prediction of Maternal and Fetal Pharmacokinetics of Dolutegravir and Raltegravir Using Physiologically Based Pharmacokinetic Modeling.

Liu Xiaomei I XI Momper Jeremiah D JD Rakhmanina Natella Y NY Green Dionna J DJ Burckart Gilbert J GJ Cressey Tim R TR Mirochnick Mark M Best Brookie M BM van den Anker John N JN Dallmann André A

Clinical pharmacokinetics 20201101 11

<h4>Background</h4>Predicting drug pharmacokinetics in pregnant women including placental drug transfer remains challenging. This study aimed to develop and evaluate maternal-fetal physiologically based pharmacokinetic models for two antiretroviral drugs, dolutegravir and raltegravir. ...[more]

PMID: 32451908

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