Ontology highlight
ABSTRACT:
SUBMITTER: Malik PRV
PROVIDER: S-EPMC6875711 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
CPT: pharmacometrics & systems pharmacology 20191019 11
The comparative performances of physiologically-based pharmacokinetic (PBPK) modeling and allometric scaling for predicting the pharmacokinetics (PKs) of large molecules in pediatrics are unknown. Therefore, both methods were evaluated for accuracy in translating knowledge of infliximab PKs from adults to children. PBPK modeling was performed using the base model for large molecules in PK-Sim version 7.4 with modifications in Mobi. Eight population PK models from literature were reconstructed an ...[more]