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Impaired liver regeneration and lipid homeostasis in CCl4 treated WDR13 deficient mice.

ABSTRACT: WDR13 - a WD repeat protein, is abundant in pancreas, liver, ovary and testis. Absence of this protein in mice has been seen to be associated with pancreatic ?-cell proliferation, hyperinsulinemia and age dependent mild obesity. Previously, we have reported that the absence of WDR13 in diabetic Leprdb/db mice helps in amelioration of fatty liver phenotype along with diabetes and systemic inflammation. This intrigued us to study direct liver injury and hepatic regeneration in Wdr13-/0 mice using hepatotoxin CCl4. In the present study we report slower hepatic regeneration in Wdr13-/0 mice as compared to their wild type littermates after CCl4 administration. Interestingly, during the regeneration phase, hepatic hypertriglyceridemia was observed in Wdr13-/0 mice. Further analyses revealed an upregulation of PPAR pathway in the liver of CCl4- administered Wdr13-/0 mice, causing de novo lipogenesis. The slower hepatic regeneration observed in CCl4 administered Wdr13-/0 mice, may be linked to liver hypertriglyceridemia because of activation of PPAR pathway.

SUBMITTER: Mishra AP 

PROVIDER: S-EPMC7666495 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Impaired liver regeneration and lipid homeostasis in CCl<sub>4</sub> treated WDR13 deficient mice.

Mishra Arun Prakash AP   Siva Archana B AB   Gurunathan Chandrashekaran C   Komala Y Y   Lakshmi B Jyothi BJ  

Laboratory animal research 20201113 1

WDR13 - a WD repeat protein, is abundant in pancreas, liver, ovary and testis. Absence of this protein in mice has been seen to be associated with pancreatic β-cell proliferation, hyperinsulinemia and age dependent mild obesity. Previously, we have reported that the absence of WDR13 in diabetic Lepr<sup>db/db</sup> mice helps in amelioration of fatty liver phenotype along with diabetes and systemic inflammation. This intrigued us to study direct liver injury and hepatic regeneration in Wdr13<sup  ...[more]

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