Feasibility study of PET dynamic imaging of [¹⁸F]DHMT for quantification of reactive oxygen species in the myocardium of large animals.

ABSTRACT:

Objectives

We aimed to develop a dynamic imaging technique for a novel PET superoxide tracer, [¹⁸F]DHMT, to allow for absolute quantification of myocardial reactive oxygen species (ROS) production in a large animal model.

Methods

Six beagle dogs underwent a single baseline dynamic [¹⁸F]DHMT PET study, whereas one animal underwent three serial dynamic studies over the course of chronic doxorubicin administration (1 mg·kg^-1·week^-1 for 15 weeks). During the scans, sequential arterial blood samples were obtained for plasma metabolite correction. The optimal compartment model and graphical analysis method were identified for kinetic modeling. Values for the left ventricular (LV) net influx rate, K_i, were reported for all the

SUBMITTER: Wu J 

PROVIDER: S-EPMC7666654 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature