Ontology highlight
ABSTRACT:
SUBMITTER: Wang RQ
PROVIDER: S-EPMC7666719 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Wang Rui-Qi RQ Chen Chong-Jian CJ Jing Yu Y Qin Jia-Yue JY Li Yan Y Chen Guo-Feng GF Zhou Wei W Li Yong-Hui YH Wang Juan J Li Da-Wei DW Zhao Hong-Mei HM Wang Bian-Hong BH Wang Li-Li LL Wang Hong H Wang Meng-Zhen MZ Gao Xiao-Ning XN Yu Li L
Cancer medicine 20200924 22
To explore the characteristics and prognostic significance of genetic mutations in acute myeloid leukemia (AML), we screened the gene mutation profile of 171 previously untreated AML patients using a next-generation sequencing technique targeting 127 genes with potential prognostic significance. A total of 390 genetic alterations were identified in 149 patients with a frequency of 87.1%. Younger age and high sensitivity to induction chemotherapy were associated with a lower number of mutations. ...[more]