Ontology highlight
ABSTRACT:
SUBMITTER: Pu J
PROVIDER: S-EPMC7667992 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Pu Jian J Wang Jianchu J Qin Zebang Z Wang Anmin A Zhang Ya Y Wu Xianjian X Wu Yi Y Li Wenchuan W Xu Zuoming Z Lu Yuan Y Tang Qianli Q Wei Huamei H
Frontiers in oncology 20201102
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in China. N6-methyladenosine (m6A) plays an important role in posttranscriptional gene regulation. METTL3 and IGF2BP2 are key genes in the m6A signal pathway and have recently been shown to play important roles in cancer development and progression. In our work, higher METTL3 and IGF2BP2 expression were found in HCC tissues and were associated with a poor prognosis. In addition, IGF2BP2 overexpression promoted HCC prolifer ...[more]