Ontology highlight
ABSTRACT:
SUBMITTER: Alshammari MB
PROVIDER: S-EPMC7668221 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Alshammari Mohammed B MB Ramadan Mohamed M Aly Ashraf A AA El-Sheref Essmat M EM Bakht Md Afroz MA Ibrahim Mahmoud A A MAA Shawky Ahmed M AM
Journal of molecular structure 20201116
We report herein a new series of synthesized <i>N</i>-substituted-2-quinolonylacetohydrazides aiming to evaluate their activity towards SARS-CoV-2. The structures of the obtained products were fully confirmed by NMR, mass, IR spectra and elemental analysis as well. Molecular docking calculations showed that most of the tested compounds possessed good binding affinity to the SARS-CoV-2 main protease (M<sup>pro</sup>) comparable to<b>Remdesivir</b>. ...[more]