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Effect of magnesium sulfate on renal colic pain: A PRISMA-compliant meta-analysis.

ABSTRACT: BACKGROUND:Magnesium sulfate (MgSO4) is widely used in analgesia for different conditions. Recent randomized controlled trials (RCTs) have evaluated the effects of MgSO4 on renal colic; however, this new evidence has not been synthesized. Thus, we conducted a systematic review and meta-analysis to assess the efficacy and safety of MgSO4 in comparison with control for renal colic. METHODS:PubMed, EMBASE, and Scopus databases were searched from inception to February 2020. We included RCTs that evaluated MgSO4 vs control for patients with renal colic. Data were independently extracted by 2 reviewers and synthesized using a random-effects model. RESULTS:Four studies with a total of 373 patients were analyzed. Intravenous MgSO4 15 to 50?mg/kg did not significantly reduce renal colic pain severity at 15?minutes (mean difference [MD]?=?0.35, 95% confidence interval [CI] -0.51 to 1.21; 2 RCTs), 30?minutes (MD?=?0.19, 95% CI -0.74 to 1.13; 4 RCTs), and 60?minutes (MD?=?-0.28, 95% CI -0.72 to 0.16; 3 RCTs) in comparison with controls. In patients who failed to respond to initial analgesics, intravenous MgSO4 15?mg/kg or 2?ml of 50% solution provided similar pain relief to ketorolac or morphine at 30?minutes (P?=?.90) and 60?minutes (P?=?.57). No significant hemodynamic changes were observed with short-term use of MgSO4 in these studies. CONCLUSION:MgSO4 provides no superior therapeutic benefits in comparison with control treatments. MgSO4 may be used as a rescue medication in patients not responding to initial analgesics. The short-term use of MgSO4 did not affect hemodynamic values.

SUBMITTER: Chen LF

PROVIDER: S-EPMC7668463 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Effect of magnesium sulfate on renal colic pain: A PRISMA-compliant meta-analysis.

Chen Liang-Fu LF Yang Chih-Hao CH Lin Ting-Yi TY Pao Po-Jia PJ Chu Karen Chia-Wen KC Hsu Chin-Wang CW Bai Chyi-Huey CH Du Ming-Hai MH Hsu Yuan-Pin YP

Medicine 20201101 46

<h4>Background</h4>Magnesium sulfate (MgSO4) is widely used in analgesia for different conditions. Recent randomized controlled trials (RCTs) have evaluated the effects of MgSO4 on renal colic; however, this new evidence has not been synthesized. Thus, we conducted a systematic review and meta-analysis to assess the efficacy and safety of MgSO4 in comparison with control for renal colic.<h4>Methods</h4>PubMed, EMBASE, and Scopus databases were searched from inception to February 2020. We include ...[more]

PMID: 33181719

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Dataset Information

Effect of magnesium sulfate on renal colic pain: A PRISMA-compliant meta-analysis.

Publications

Effect of magnesium sulfate on renal colic pain: A PRISMA-compliant meta-analysis.

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