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Disparities of National Lung Cancer Screening Guidelines in the US Population.


ABSTRACT: BACKGROUND:Current US Preventive Services Task Force (USPSTF) lung cancer screening guidelines are based on smoking history and age (55-80?years). These guidelines may miss those at higher risk, even at lower exposures of smoking or younger ages, because of other risk factors such as race, family history, or comorbidity. In this study, we characterized the demographic and clinical profiles of those selected by risk-based screening criteria but were missed by USPSTF guidelines in younger (50-54?years) and older (71-80?years) age groups. METHODS:We used data from the National Health Interview Survey, the CISNET Smoking History Generator, and results of logistic prediction models to simulate lifetime lung cancer risk-factor data for 100 000 individuals in the 1950-1960 birth cohorts. We calculated age-specific 6-year lung cancer risk for each individual from ages 50 to 90?years using the PLCOm2012 model and evaluated age-specific screening eligibility by USPSTF guidelines and by risk-based criteria (varying thresholds between 1.3% and 2.5%). RESULTS:In the 1950 birth cohort, 5.4% would have been ineligible for screening by USPSTF criteria in their younger ages but eligible based on risk-based criteria. Similarly, 10.4% of the cohort would be ineligible for screening by USPSTF in older ages. Notably, high proportions of blacks were ineligible for screening by USPSTF criteria at younger (15.6%) and older (14.2%) ages, which were statistically significantly greater than those of whites (4.8% and 10.8%, respectively; P?

SUBMITTER: Han SS 

PROVIDER: S-EPMC7669226 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Disparities of National Lung Cancer Screening Guidelines in the US Population.

Han Summer S SS   Chow Eric E   Ten Haaf Kevin K   Toumazis Iakovos I   Cao Pianpian P   Bastani Mehrad M   Tammemagi Martin M   Jeon Jihyoun J   Feuer Eric J EJ   Meza Rafael R   Plevritis Sylvia K SK  

Journal of the National Cancer Institute 20201101 11


<h4>Background</h4>Current US Preventive Services Task Force (USPSTF) lung cancer screening guidelines are based on smoking history and age (55-80 years). These guidelines may miss those at higher risk, even at lower exposures of smoking or younger ages, because of other risk factors such as race, family history, or comorbidity. In this study, we characterized the demographic and clinical profiles of those selected by risk-based screening criteria but were missed by USPSTF guidelines in younger  ...[more]

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