The association of non-alcoholic fatty liver disease and cardiac structure and function-Framingham Heart Study.

ABSTRACT:

Background & aims

Non-alcoholic fatty liver disease confers increased risk for cardiovascular disease, including heart failure (HF), for reasons that remain unclear. Possible pathways could involve an association of liver fat with cardiac structural or functional abnormalities even after accounting for body size.

Methods

We analysed N = 2356 Framingham Heart Study participants (age 52 ± 12 years, 52% women) who underwent echocardiography and standardized computed tomography measures of liver fat.

Results

In cross-sectional multivariable regression models adjusted for age, gender, cohort and cardiovascular risk factors, liver fat was positively associated with left ventricular (LV) mass (β = 1.45; 95% confidence interval (CI): 0.01, 2.88), LV wall thickness (β = 0.01;

SUBMITTER: Chiu LS 

PROVIDER: S-EPMC7669676 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature