Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen NUN
PROVIDER: S-EPMC7670845 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Nguyen Ngoc Uyen Nhi NUN Canseco Diana C DC Xiao Feng F Nakada Yuji Y Li Shujuan S Lam Nicholas T NT Muralidhar Shalini A SA Savla Jainy J JJ Hill Joseph A JA Le Victor V Zidan Kareem A KA El-Feky Hamed W HW Wang Zhaoning Z Ahmed Mahmoud Salama MS Hubbi Maimon E ME Menendez-Montes Ivan I Moon Jesung J Ali Shah R SR Le Victoria V Villalobos Elisa E Mohamed Magid S MS Elhelaly Waleed M WM Thet Suwannee S Anene-Nzelu Chukwuemeka George CG Tan Wilson Lek Wen WLW Foo Roger S RS Meng Xun X Kanchwala Mohammed M Xing Chao C Roy Jagoree J Cyert Martha S MS Rothermel Beverly A BA Sadek Hesham A HA
Nature 20200422 7811
A major factor in the progression to heart failure in humans is the inability of the adult heart to repair itself after injury. We recently demonstrated that the early postnatal mammalian heart is capable of regeneration following injury through proliferation of preexisting cardiomyocytes<sup>1,2</sup> and that Meis1, a three amino acid loop extension (TALE) family homeodomain transcription factor, translocates to cardiomyocyte nuclei shortly after birth and mediates postnatal cell cycle arrest< ...[more]