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Purine metabolism promotes radioresistance and is a therapeutic target in glioblastoma.


ABSTRACT: Profound intratumoral genomic heterogeneity has limited the ability of targeted therapies to overcome therapy resistance in glioblastoma. We have defined purine metabolism as a key mediator of DNA repair and radiation resistance in glioblastoma. Because many glioblastoma oncogenic drivers activate purine metabolism, its inhibition may overcome therapy resistance despite intratumoral genomic heterogeneity.

SUBMITTER: Zhou W 

PROVIDER: S-EPMC7671052 | biostudies-literature |

REPOSITORIES: biostudies-literature

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