HOTAIR is a therapeutic target in glioblastoma.
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ABSTRACT:
SUBMITTER: Zhou X
PROVIDER: S-EPMC4480757 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Publications
HOTAIR is a therapeutic target in glioblastoma.
Zhou Xuan X Ren Yu Y Zhang Jing J Zhang Chuanbao C Zhang Kailiang K Han Lei L Kong Lingping L Wei Jianwei J Chen Luyue L Yang Jingxuan J Wang Qixue Q Zhang Jianning J Yang Yuqi Y Jiang Tao T Li Min M Kang Chunsheng C
Oncotarget 20150401 10
HOTAIR is a negative prognostic factor and is overexpressed in multiple human cancers including glioblastoma multiform (GBM). Survival analysis of Chinese Glioma Genome Atlas (CGGA) patient data indicated that high HOTAIR expression was associated with poor outcome in GBM patients. NLK (Nemo-like kinase), a negative regulator of the β-catenin pathway, was negatively correlated with HOTAIR expression. When the β-catenin pathway was inhibited, GBM cells became susceptible to cell cycle arrest and ...[more]
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